Lena Wilson got her start in show business on the TOBA vaudeville circuit sometime around 1918. She had a musical act with her brother Danny Wilson, who later married Blues singer Edith Wilson. Their act became a trio after the marriage. In 1921 Lena settled in New York, became a popular figure in the Black theatre scene in the city and appeared in dozens of musical revues up until around 1931. Her recording career began in 1922 and continued until 1924. She didn't record again until 1930. After her recording career ended she continued to perform in clubs in the New York area until the mid-1930s. She was married to jazz violinist Shrimp Jones. Lena Wilson is reported to have died of pneumonia in 1939.